マルチレベル並列化とアプリケーション指向データレイアウトを用いるハードウェアアクセラレータの設計と実装

学位の種別: 課程博士審査委員会委員 : （主査）東京大学教授 稲葉 雅幸, 東京大学教授 須田 礼仁, 東京大学教授 五十嵐 健夫, 東京大学教授 山西 健司, 東京大学准教授 稲葉 真理, 東京大学講師 中山 英樹University of Tokyo(東京大学

Diffuse Endobronchial Wall Spread of Metastatic Breast Cancer

We present here a case of diffuse tracheobronchial wall spread of metastatic breast cancer who was successfully treated with trastuzumab plus vinorelbine chemotherapy. The patient had a left radical mastectomy for breast cancer in March 2000 and developed persistent cough and dyspnea in November 2006. Pulmonary function test demonstrated an obstructive pattern. Chest computed tomography showed a wall thickening of trachea and right side bronchus, but radiographic findings including 18F-fluorodeoxyglucose positron emission tomography failed to detect the locations of disease in the lung. The findings on bronchofiberscopy showed edematous tracheobronchial mucosa, but also failed to visually detect direct masses. Transbronchial biopsy specimens revealed involvement of metastatic breast cancer. The patient was treated with trastuzumab plus vinorelbine chemotherapy and the wall thickening of bronchial tree and clinical symptoms were improved. Although endobronchial metastasis in metastatic breast cancer is not uncommon, diffuse spread without forming intraluminal mass is extremely rare. The pattern of endobronchial metastasis should be considered in patients with malignancies even when radiographic abnormalities are undetectable

Development of Attitude Sensor using Deep Learning

A new method for attitude determination utilizing color earth images taken with COTS visible light camera is presented. The traditional earth camera has been used for coarse attitude determination by detecting the edge of the earth, and therefore it can only provide coarse and 2-axis information. In contrast, our method recognizes the ground pattern with an accuracy of sub-degrees and can provide 3-axis attitude information by comparing the detected ground pattern and the global map. Moreover, this method has advantages in the size, mass and cost of the detector system which consists of a cheap optical color camera and a single board computer. To demonstrate the method in space, we have developed a sensor system named “Deep Learning Attitude Sensor (DLAS)”. DLAS uses COTS camera modules and single board computers to reduce the cost. The obtained images are promptly analyzed with a newly developed real-time image recognition algorithms

Variable Shape Attitude Control Demonstration with Microsat Hibari

This paper presents the ongoing feasibility study and bus system for microsatellite “Hibari”. The main technical missions for Hibari is called “Variable Shape Attitude Control (VSAC)”. This VSAC is based on an idea to utilize a reaction torque when a part of the satellite structure, for example, solar array paddles is appropriately rotated by actuators. The previous research concluded that VSAC successfully achieved the rapid maneuvering while maintain the high attitude stability against disturbances [1], and thus, it can be applied to a variety of advanced attitude control missions. Hibari project also aims at its application to astronomical mission requiring high pointing stability and agile maneuvering. This paper is mainly comprised of 3 parts: detail mission statement, ongoing feasibility studies and bus system configuration. First, we mention the mission requirement and detail mission sequence for both technical and science missions. Second, we show the ongoing feasibility studies to confirm that all mission requirement is satisfied by VSAC. Third, this paper describes each subsystem configuration to meet the system requirement stated in the mission’s section. And then, we wrap up in the conclusion section and stated the future study for advanced VSAC use in the end

Developmental profile of localized spontaneous Ca2+ release events in the dendrites of rat hippocampal pyramidal neurons

Author Posting. © The Author(s), 2012. This is the author's version of the work. It is posted here by permission of Elsevier B.V. for personal use, not for redistribution. The definitive version was published in Cell Calcium 52 (2012): 422-432, doi:10.1016/j.ceca.2012.08.001.Recent experiments demonstrate that localized spontaneous Ca2+ release events can be detected in the dendrites of pyramidal cells in the hippocampus and other neurons (J. Neurosci. 29:7833-7845, 2009). These events have some properties that resemble ryanodine receptor mediated “sparks” in myocytes, and some that resemble IP3 receptor mediated “puffs” in oocytes. They can be detected in the dendrites of rats of all tested ages between P3 and P80 (with sparser sampling in older rats), suggesting that they serve a general signaling function and are not just important in development. However, in younger rats the amplitudes of the events are larger than the amplitudes in older animals and almost as large as the amplitudes of Ca2+ signals from backpropagating action potentials (bAPs). The rise time of the event signal is fast at all ages and is comparable to the rise time of the bAP fluorescence signal at the same dendritic location. The decay time is slower in younger animals, primarily because of weaker Ca2+ extrusion mechanisms at that age. Diffusion away from a brief localized source is the major determinant of decay at all ages. A simple computational model closely simulates these events with extrusion rate the only age dependent variable.Supported in part by NIH grant NS-016295

The Japanese space gravitational wave antenna; DECIGO

DECi-hertz Interferometer Gravitational wave Observatory (DECIGO) is the future Japanese space gravitational wave antenna. DECIGO is expected to open a new window of observation for gravitational wave astronomy especially between 0.1 Hz and 10 Hz, revealing various mysteries of the universe such as dark energy, formation mechanism of supermassive black holes, and inflation of the universe. The pre-conceptual design of DECIGO consists of three drag-free spacecraft, whose relative displacements are measured by a differential Fabry– Perot Michelson interferometer. We plan to launch two missions, DECIGO pathfinder and pre- DECIGO first and finally DECIGO in 2024

DECIGO pathfinder

DECIGO pathfinder (DPF) is a milestone satellite mission for DECIGO (DECi-hertz Interferometer Gravitational wave Observatory) which is a future space gravitational wave antenna. DECIGO is expected to provide us fruitful insights into the universe, in particular about dark energy, a formation mechanism of supermassive black holes, and the inflation of the universe. Since DECIGO will be an extremely large mission which will formed by three drag-free spacecraft with 1000m separation, it is significant to gain the technical feasibility of DECIGO before its planned launch in 2024. Thus, we are planning to launch two milestone missions: DPF and pre-DECIGO. The conceptual design and current status of the first milestone mission, DPF, are reviewed in this article

EGFR mutation and ALK fusion-positive non-small cell lung cancer: a multicenter prospective cohort study in Nagano Prefecture, Japan

Introduction. We prospectively examined current clinical practices in patients with inoperable epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase (ALK) fusion-positive (EGFR+ and ALK+, respectively) non-small cell lung cancer (NSCLC) in Nagano Prefecture, Japan.  Material and methods. The study population consisted of newly diagnosed patients with inoperable EGFR+ and ALK+ NSCLC in 14 hospitals in Nagano between May 2016 and March 2019. Both initial and subsequent treatment decisions were made at the discretion of the attending physician.  Results. A total of 281 patients with EGFR+ NSCLC (mean age, 74 years, 59.1% female) and 26 patients with ALK+ NSCLC (mean age, 66 years, 53.8% female) were included in the study. The study population consisted of 148/107/29/20/3 cases with performance status 0/1/2/3/4 and 6/2/31/194/75 cases with clinical stage I/II/III/IV/recurrence, respectively. First-line therapy with tyrosine kinase inhibitors was performed in 259 (92.2%) and 22 (84.6%) patients with EGFR+ and ALK+ NSCLC, respectively. The median overall survival rate was 41.2 months (95% CI 36.8–45.6 months) with EGFR+. It was not reached with ALK+ .  Conclusions. This observational analysis represents a valuable resource for evaluating the outcomes of treatment in patients with NSCLC

Soil microbial succession along a vegetation development sequence in a volcanic desert on Mount Fuji, Japan

第2回極域科学シンポジウム/第33回極域生物シンポジウム 11月18日（金） 統計数理研究所 3階リフレッシュフロ